Restless Leg Syndrome
Natural Progesterone Versus Synthetic Progestins

Progestins (Megestrol & Provera) interfere with Natural Progesterone's Healing Effect on Restless Leg Syndrome

by Peter Eckhart, MD

Do Not Use Progestins With Natural Progesterone Otherwise Your Restless Leg Syndrome will NOT be Cured.

Natural Progesterone is the same bioidentical hormone that a woman�s body produces during the second half of her menstrual cycle (20 mg/day) and in large amounts during pregnancy (third trimester 400 mg/day). Natural Progesterone is safe for a pregnant woman, and safe for the unborn child. Fertility Medical Doctors (test tube doctors) routinely use Natural Progesterone to prevent 1st trimester miscarriage in pregnant women. Women that are pregnant multiple times are known to have smaller chances of breast cancer and endometrial cancer. During one day of third trimester pregnancy, the woman�s body produces 400 mg/day of Natural Progesterone. Typically, Restless Leg Syndrome patients use 20 mg/day � 40 mg/day of topical Natural Progesterone. This curative dose is 10 times less than one day of third trimester pregnancy.

In contrast, according to the PDR (Physicians Desk Reference) prescription brand name Progestins CAUSE cancer. In contrast, according to the PDR (Physicians Desk Reference) prescription brand name Progestins CAUSE birth defects.

Synthetic Progestins are different from Natural Progesterone in affecting Restless Leg Syndrome patients.

Synthetic Progestins such as Megestrol and Provera compete and fit into with the receptor/binding sites normally reserved for Natural Progesterone. Progesterone taken together with these synthetic hormones will NOT work. And your breast Restless Leg Syndrome will not disappear. These synthetic prescription Progestins will block Natural Progesterone and prevent Restless Leg Syndrome healing.

Progestins Block Restless Leg Syndrome Healing

Your body produces three different estrogens; they are estriol, estrone, and estradiol. However, there is only one and only one progesterone that your body produces. Progesterone is Naturallly found in the body.  Megestrol and Provera is NOT.It is called progesterone or Natural Progesterone. It is the precursor to other hormones such as the three estrogens, testosterone, and cortisol. Yes, women also produce small amounts of testosterone. Natural hormones that your body produces cannot be patented because they are naturally found in nature. If you are a business, and come out with a natural progesterone cream for sale, anyone can copy your cream. There is no protection from competition.

Thus, pharmaceutical companies take the natural progesterone compound that your body makes and purposely alter the molecule to gain patent protection, profits, and a relief from competition. They need to support the costs of 100 million dollars of research and clinical trials with a protected patented drug. Also they need to pay their drug representatives $60,000 to $100,000 per year. They need to pay for fancy expensive television ads. That is the pharmaceutical drug company�s cost structure. However, since the progesterone molecule is altered, the molecule is no longer progesterone. As a result, these altered molecules, progestins, have side effects like CANCER and BIRTH DEFECTS. Progestins will NOT help Restless Leg Syndrome. And yes, progestins are found in birth control pills.

Chemistry Structures of Natural Progesterone and Synthetic Progestins

Natural Progesterone

Provera (artificial)

Megestrol (artificial)

Natural Progesterone is what your body produces. Provera and Megestrol are patented artificial hormones with serious side effects like CANCER and Birth Defects. Artificial prescription progestins will NOT cure Restless Leg Syndrome! Provera and Megestrol will block the Restless Leg Syndrome healing effect of Natural Progesterone.

Do NOT be intimidated by the molecules above. Remember those pictures you looked at as a kid and played as a game. You compared each picture to the other looking for differences.

The pharmaceutical industry must modify the natural hormone to patent it and thus be the only one to be able to sell it. That is how the pharmaceutical industry gets large profits to support its cost structure.

Estradiol and Testosterone Differences and Similarities

Small molecular differences can have large differences that affecting human and animal. Two hormones are shown below. The first is testosterone, the "male" hormone. Testosterone induces malenessThe second is estradiol, the potent "female" hormone. Even though molecular differences are very small and the hormones look very similar, testosterone tells the body it is male. Estradiol tells the body it is female. Small differences in molecular structure are the difference between male and female. Now, think of the artificial hormones (prescription Progestins) and the side effects that they will have.

Estradiol and Testosterone               Estradiol                                                                Testosterone

Estradiol and Testosterone are very similar molecular structures. However, they produce the maleness and femaleness in animals and humans.

Side Effects of Progesterone

A woman produces about 20 mg per day of natural progesterone from her ovaries during the latter part of the menstrual cycle before age 35. During the first trimester of pregnancy the corpus luteum on the ovary produces progesterone. During the second and third trimester of pregnancy, the placenta begins to produce progesterone. During one day of third trimester pregnancy, the placenta produces as much as 400 mg per day. That is why it is called progesterone. Pro meaning "for". Gesterone meaning "gestation". At physiologic doses Restless Leg Syndrome will be cured with Natural Progesterone. 20-40 mg per day applied to the skin has little or no side effects unless xenoestrogens and phytoestrogens are NOT eliminated from the environment.

The side effects of xenoestrogens and phytoestrogens are amplified when taking Natural Progesterone, IF and only if you do NOT cut out xenoestrogens and phytoestrogens. The answer is to eliminate the xenoestrogens and phytoestrogens from the environment. See the side effects here.

There is some slight drowsiness. Thus, you can apply progesterone on your skin just before bed time to give you a nice sleep induction. If you are using too much progesterone you may feel emotionally elated and also have an increase in sex drive. If you are taking too much progesterone when you stop you may also feel slightly emotionally depressed. This is why women have post partum depression. After the placenta is delivered, their bodies experience a drop in progesterone, and the women experience an emotional depression.

Progesterone induces sleep At high doses (10% progesterone cream or 2,800mg progesterone/oz of cream) for many years, I have heard of anecdotal reports of mental confusion which cleared after several months of discontinued use.

With physiologic doses of natural progesterone 20-40 mg/day out of 7000 patients I have never seen one case of mental confusion.

Side Effects of Progestins

Again, artificial progestins will NOT help Restless Leg Syndrome. Because of alterations to the Natural Progesterone molecule, the drug has side effects. The following is a partial list of side effects of Provera (medroxyprogesterone acetate) from 1993 PDR (Physician's Desk Reference)


Increased risk of birth defects such as heart and limb defects if taken during the first four months of pregnancy.

Beagle dogs given this drug developed malignant mammary nodules. ("malignant mammary nodules" is the same as BREAST CANCER).Beagle Dogs get breast cancer from Progestins

Discontinue this drug if there is a sudden or partial loss of vision.

This drug passes into breast milk consequences unknown.

May contribute to thrombophlebitis, pulmonary embolism, and cerebral thrombosis.


May cause fluid retention, epilepsy, migraine, asthma, cardiac or renal dysfunction.

May cause breakthrough bleeding or menstrual irregularities.

May cause or contribute to depression.Progesterone can help with Restless Leg Syndrome.

The effect of prolonged use of this drug on pituitary, ovarian, adrenal, hepatic, or uterine function is unknown.

May decrease glucose tolerance; diabetic patients must be carefully monitored.

May increase the thrombotic disorders associated with estrogens.

Stopping the Progestin

Progestins are found in hormone replacement therapy (HRT) and birth control pills. Dr. John Lee recommends stopping them.

Dr. Lee maintains that a woman on a progestin such as Provera (Medroxyprogesterone acetate) or Megestrol should stop the progestin. Immediately lower the dose by 1/2 and lower it more the second month. By the third month the progestin may be completely stopped. There are two reasons for this method.

The first reason is that the progestin competes for the binding sites of progesterone. Thus, continued use of the progestin will block the effect of progesterone.

The second reason is that plasma progesterone levels will not reach a maximum level until the 2nd or 3rd month of use. Initially, in progesterone deficient patients, much of the progesterone is absorbed into body fat. With continued use, fat levels of progesterone reach an equilibrium such that successive doses of progesterone result in increased blood levels and stronger physiological effects. Thus, natural progesterone applications usually takes 2 to 3 months accompanied by xenestrogen and phytoestrogen elimination for Restless Leg Syndrome to completely disappear.

However, you should notice some difference after about 10 days. Breasts and should become LESS sore. Premenstrual bloating should become less. IF your breasts are becoming MORE sore and bloating is becoming worse then you should stop the Natural Progesterone, stop all xenoestrogens for 1-2 months, and then try to take Natural Progesterone again. See Troubleshooting Restless Leg Syndrome Therapy Failure.

Where Does Natural Progesterone that stops Restless Leg Syndrome and Progestins that compete with Natural Progesterone Come From?

Progestins and conjugated estrogen used as birth control pills were discovered by the pharmaceutical companies while looking for a fertility drug by studying folk medicine in Mexico. Wild yams were found to have a diosgenin that had the base compound of progesterone in it. Progesterone Yam leavesTo preserve profits, conjugated artificial estrogens and artificial progestins were invented and patented to protect market share. These artificial hormones have serious side effects. The pharmaceutical companies maintain large farms of these yams to give them the base compounds for the manufacturing of their artificial hormones. All or most of the natural progesterone is also made from these yams. The yams contain a compound called a diosgenin. Disogenin has the progesterone molecule in it. Some molecules are cleaved off of the diosgenin, and progesterone is the result.

The Bottom Line

Summary - Natural Progesterone versus Progestins for Restless Leg Syndrome

  • Natural Progesterone is used by Fertility Medical Doctors for Miscarriage.
  • Synthetic Prescription Progestins cause cancer and birth defects.
  • A pregnant woman during the last third of pregnancy produces 400 mg/day of Natural Progesterone. A good Natural Progesesterone Dose is 20-60 mg/day.
  • Do NOT use Progestins with Natural Progesterone. As this Progestin will block Natural Progesterone.

Buy Natural Progesterone!


PMS Improving

I have to go to work but wanted to send a quick email to tell you what a difference this has made in my life.

The first month I had to stop taking and eliminate some more products from my life. The second month though has been going great! I only drink water and some juices now and have purchased both olive oil soap from Elysian Dream and the laundry detergent from Nature it! I am having somewhat tender breasts now (this week) and think that it may be due to the oncoming menstrual cycle. Anyway....the other differences I have experienced are incredible. My mood is so much, even keel and feeling great! Also I have lost 15 pounds in two (2) months without even really trying (this was not something intentional). I still eat the same amount...only now I eat better. The extra fat around my waste line is leaving and almost gone. I am 39 years old and have struggled with monthly issues and breast pain for quite some time. This year the breast pain was becoming extremely severe and my doctor didn't really have any answers. Also a couple lumps were found on my mammogram (diagnosed as cysts). I will write more later to you about this but must leave for work now. Oh, my weight, two months ago was 145 pounds and now I am 130 pounds (had to purchase new clothes). I am getting my body back and my skin has cleared up and my hair feels great (It seemed as though my hair kept thinning and now it has stopped in that I don't seem to have as much falling out when I run my fingers through it). Why don't more people know about this! I have begun telling everyone I know, that will listen.......

Thank you for having your website and sharing this news,


Port Richey, FL

I just placed my second order this morning.

Nov. 29, 2007


Lost Weight
Just a short note to let you know that I am so great. I have removed as many xenoestrogens as possible from my environment, skin and diet, as you advised, for nearly a month now and the improvement has been amazing. I am using the Nature Clean powder detergent, no dryer sheets, Elysian Dream products for hair and skin (fragrance free and those without rosemary and lavendar oils, only ones with olive oil, and the organic, fragrance-free shea butter), and the crystal deodorant vs. regular deodorant (AMAZINGLY better), and we changed all of our household products to the Nature Clean line and no longer use any antibacterial foaming soaps or anything. Just Grandpa's baking soda soap for regular hand washing.

I have lost seven pounds this month, my last period cycle was 28 days (who knew!) and my hair has started to grow back (after four years of thinning!!). The biggest thing is that my body is, quiet, for lack of a better way to describe it! No stomach aches, bloating or headaches, no breast pain and my moods are more consistent day to day. My energy is coming back, skin is great -- I can't believe it.

I think I have finally tapped into what has been ailing me for the past six years and I couldn't be more pleased! I plan to use these products regardless... the "clean" feeling from them is just so great. My husband has been using them too, and we are thrilled!!

Thank you so much!


D.S., Huntington, New York

Dec. 19, 2007

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